Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases
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چکیده
منابع مشابه
Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.
Statins are widely used hypocholesterolemic drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme of the mevalonate pathway whose biosynthetic end product is cholesterol. In addition to lowering circulating cholesterol, statins perturb the composition of cell membranes, resulting in disruption of lipid rafts, which function as signaling platforms i...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2006
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200636567